TNF Transduced TIL
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TNF Transduced TIL Definition
A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity. Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04)
TNF Transduced TIL Synonyms
TNF Transduced TIL, TNF Gene Transduced TIL
Terms in TNF Transduced TIL category
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