TPMT-3C Allele

Cancer Terms -> Gene -> Enzyme Gene -> Transferase Gene -> Methyltransferase Gene -> TPMT Gene -> TPMT-3C Allele

TPMT-3C Allele Definition

Human TPMT*3C allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, a variant form of the TPMT wild-type allele, encodes thiopurine S-methyltransferase protein. TPMT*3C allele exhibits a clinically-relevant SNP (c.874A>G) that results in an Y240C coding change. This alteration in protein sequence decreases the enzymatic activity of the protein encoded by this allelic variant.

TPMT-3C Allele Synonyms

TPMT*3C Allele, TPMT, Y240C, TPMT, c.874A>G, TPMT-3C

Terms in TPMT-3C Allele category

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