Cancer Terms

TRADD Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> TRADD Protein

TRADD Protein Definition

TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction. TRADD contains a death domain, similar to that of TNFR1, capable of mediating TRADD oligomerization, interaction with the TNFR1 death domain, stimulation of apoptosis, and NFKB activation. TNF-induced apoptosis involves TRADD-mediated ICE cysteine protease activation. NFKB activation by TRADD involves a different pathway. (from J Leukoc Biol 1998. 63:678, OMIM 603500, and NCI)

TRADD Protein Synonyms

TRADD Protein, TNF Receptor-Associated Protein with a Death Domain, TNFR1-Associated Death Domain Protein, TNFRSF1A-Associated via Death Domain, TRADD

Terms in TRADD Protein category



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