TRAIL Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Cytokine -> Tumor Necrosis Factor Family Protein -> TRAIL Protein

TRAIL Protein Definition

Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI)

TRAIL Protein Synonyms

Tumor Necrosis Factor Ligand Superfamily Member 10, APO2 Ligand, APO2L, Apo-2 Ligand, Apo-2L, TL2, TNF-Related Apoptosis Inducing Ligand, TNF-Related Apoptosis Inducing Ligand TRAIL, TNF-Related Apoptosis-Inducing Ligand, TNFSF10, TNFSF10 Protein, TRAIL, TRAIL Protein, Tumor Necrosis Factor Ligand Superfamily, Member 10

TRAIL Protein

TRAIL Protein Definition

TRAIL Protein Synonyms

Terms in TRAIL Protein category