TTI-237
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Antineoplastic Agent ->
Antimitotic Agent ->
Tubulin Binding Agent ->
Vinca-Site Binding Agent -> TTI-237
TTI-237 Definition
A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.
TTI-237 Synonyms
TTI-237, TTI 237
Terms in TTI-237 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.