TTK Protein Kinase
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TTK Protein Kinase Definition
Expressed as a 4-kb mRNA in proliferating cells by human TTK Gene (Ser/Thr Kinase Family), 841-aa 95-kDa TTK Protein Kinase is a likely dual-specificity kinase since it phosphorylates proteins on tyrosine as well as serine and threonine. TTK is probably associated with kinetochore or centrosome function in cell proliferation. Kinetochore-associated Mps1 kinase (Xenopus) is necessary to establish and maintain the mitotic checkpoint. Required for kinetochore recruitment and retention of active CENPE, Mps1 is necessary for Mad1 and Mad2 kinetochore association and inhibition of the Anaphase-Promoting Complex/Cyclosome. Mps1 (mouse), a Cdk2 substrate, regulates centrosome duplication jointly with Cdk2. By regulating Mps1 S phase stability, Cdk2 promotes centrosome duplication by Mps1. (NCI)
TTK Protein Kinase Synonyms
TTK Protein Kinase, Dual Specificity Protein Kinase TTK, ESK, ESK Homologue, MPS1L1, Monopolar Spindle 1-Like 1, PYT, Phosphotyrosine-Picked Threonine Kinase, TTK
Terms in TTK Protein Kinase category
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