Taxane-Site Binding Agent

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimitotic Agent -> Tubulin Binding Agent -> Taxane-Site Binding Agent

Taxane-Site Binding Agent Definition

A class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. Interfering with microtubule dynamics, these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.

Taxane-Site Binding Agent Synonyms

Taxane-Pocket Binding Agent, Taxane-Site Binding Agent

Terms in Taxane-Site Binding Agent category

Docetaxel Emulsion ANX-514
Oral Milataxel
Paclitaxel Preparation