Telomere Length Maintenance

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> DNA Maintenance Process -> DNA Maintenance -> Telomere Maintenance -> Telomere Length Maintenance

Telomere Length Maintenance Definition

Telomeres in human cancer cells consist of a tandem array of telomeric DNA repeats bound to a specialized telomeric proteins. Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. Both telomerase and recombination can lengthen telomeres. (from PMID 11850780 and NCI)

Telomere Length Maintenance Synonyms

Telomere Length Maintenance, Length Maintenance

Terms in Telomere Length Maintenance category

Elongation by Telomerase
Telomere Recombination