Thompson-Friedenreich Antigen
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Thompson-Friedenreich Antigen Definition
A type 1 core O-glycan with potential immunotherapeutic property. Thomsen-Friedenreich (TF) antigen, a galactose disaccharide, is normally O-linked to serine or threonine residue of mucins (MUC1), a transmembrane glycoprotein overexpressed on epithelial cell surface of a variety of tumor cells. The expression of this antigen is associated with tumor cell adhesion, tissue invasion and aggressiveness. When administered in a vaccine formulation, TF antigen may stimulate a cytotoxic T cell response against tumors expressing TF epitope, which may result in a reduction in tumor size.
Thompson-Friedenreich Antigen Synonyms
Thomsen-Friedenreich Antigen, Antigen, Thomsen-Friedenreich, TF(c)
Terms in Thompson-Friedenreich Antigen category
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