Three Prime Repair Exonuclease 2
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DNA Repair Protein -> Three Prime Repair Exonuclease 2
Three Prime Repair Exonuclease 2 Definition
Encoded as alternative isoforms by TREX2 Gene, Three Prime Repair Exonuclease 2 contains 3 conserved exonuclease motifs and catalyzes nucleoside monophosphate excision from 3-prime DNA termini and may be a subunit of DNA polymerase III. 26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame of TREX2 Gene, producing a protein structurally unrelated to the other isoforms that interacts with Ubiquitin C-Terminal Hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. Ubiquitin C-Terminal Hydrolases (UCH) hydrolyze C-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but do not deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (NCI)
Three Prime Repair Exonuclease 2 Synonyms
Three Prime Repair Exonuclease 2, 26S Proteasome-Associated UCH Interacting Protein 1, 3'-5' Exonuclease TREX2, TREX2, Three Prime Repair Exonuclease 2 Isoform UIP1, UIP1, XQ28ORF
Terms in Three Prime Repair Exonuclease 2 category
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