Thymidylate Synthase
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Methyltransferase -> Thymidylate Synthase
Thymidylate Synthase Definition
Human thymidylate synthetase protein (312 aa, 36 kDa) is encoded by the human (TYMS) gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.
Thymidylate Synthase Synonyms
Thymidylate Synthase, EC 2.1.1.45, TMP synthetase, TYMS, Thymidylate Synthetase, dTMP Synthase
Terms in Thymidylate Synthase category
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