Tissue Plasminogen Activator
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Plasminogen Activator -> Tissue Plasminogen Activator
Tissue Plasminogen Activator Definition
A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)
Tissue Plasminogen Activator Synonyms
Tissue Plasminogen Activator, Activase, Alteplase, PLAT, Reteplase, T-Plasminogen Activator, TPA, Tissue-Type Plasminogen Activator, t-PA
Terms in Tissue Plasminogen Activator category
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