Cancer Terms

Tissue Plasminogen Activator

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Serine Protease -> Plasminogen Activator -> Tissue Plasminogen Activator

Tissue Plasminogen Activator Definition

A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)

Tissue Plasminogen Activator Synonyms

Tissue Plasminogen Activator, Activase, Alteplase, PLAT, Reteplase, T-Plasminogen Activator, TPA, Tissue-Type Plasminogen Activator, t-PA

Terms in Tissue Plasminogen Activator category



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