Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin
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Camptothecin Analogue -> Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin
Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin Definition
A highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and triggers programmed cell death. SN2310 emulsion provides longer circulation time and potentiates drug exposure as compared to the unconjugated SN-38.
Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin Synonyms
Tenifatecan, (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin- 9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl Butanedioate, SN-2310, SN2310, Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin
Terms in Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin category
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