Tolcapone
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Agent Affecting Nervous System ->
Antiparkinsonian Agent -> Tolcapone
Tolcapone Definition
A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa.
Tolcapone Synonyms
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone, Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-, TOLCAPONE, Tasmar
Terms in Tolcapone category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.