Topoisomerase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase

Topoisomerase Definition

Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin.

Topoisomerase Synonyms

Topoisomerase

Terms in Topoisomerase category

Topoisomerase-I
Topoisomerase-II
Topoisomerase-III