Topoisomerase-I
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Isomerase ->
Topoisomerase -> Topoisomerase-I
Topoisomerase-I Definition
Encoded by human TOP1 Gene (TOPI Family), 765-aa 90.7-kD monomeric DNA Topoisomerase I catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI)
Topoisomerase-I Synonyms
Topoisomerase I, DNA Topoisomerase I, TOP1, Topo I, Topoisomerase (DNA) I, Topoisomerase, DNA, I, Type I DNA Topoisomerase
Terms in Topoisomerase-I category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.