Topoisomerase-I Inhibitor
Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor
Topoisomerase-I Inhibitor Definition
Compounds that inhibit the action of topoisomerase I (see Topoisomerase Inhibitors). The alkaloid camptothecin is the most commonly used inhibitor of topoisomerase I. Water-soluble derivatives of camptothecin, such as CPT-11 and topotecan, have been examined for antineoplastic activity in colorectal cancer, non--small-cell lung cancer, lymphoma, ovarian cancer, head and neck cancer, pancreatic cancer, and breast cancerTopoisomerase-I Inhibitor Synonyms
Topoisomerase-I Inhibitor, Topoisomerase-I InhibitorsTerms in Topoisomerase-I Inhibitor category
Aerosolized Liposomal 9-NitrocamptothecinAfeletecan
Aminocamptothecin Colloidal Dispersion
Camptothecin
Camptothecin Analogue
Camptothecin Polyglutamate
Camptothecin Sodium
Cyclodextrin-Based Polymer-Camptothecin
Edotecarin
Liposomal Irinotecan
Lurtotecan Liposome
Oral Topotecan Hydrochloride
Pegylated Irinotecan NKTR 102
Polyethyleneglycol-7-ethyl-10-hydroxycamptothecin
Polymeric Camptothecin Prodrug XMT-1001
S-CKD602
SN-38-Loaded Polymeric Micelle
Topotecan Hydrochloride Liposomes
beta-Lapachone