Topoisomerase-II

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase -> Topoisomerase-II

Topoisomerase-II Definition

Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI)

Topoisomerase-II Synonyms

Topoisomerase II, DNA Topoisomerase II, Topo II

Terms in Topoisomerase-II category

Topoisomerase-II Alpha
Topoisomerase-II Beta