Cancer Terms

Topoisomerase-II Alpha

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase -> Topoisomerase-II -> Topoisomerase-II Alpha

Topoisomerase-II Alpha Definition

Encoded by human TOP2A Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa) control DNA topology. TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Topoisomerase-II Alpha Synonyms

Topoisomerase II Alpha, DNA Topoisomerase II, DNA Topoisomerase II, 170 kD, DNA Topoisomerase II, Alpha Isozyme, DNA Topoisomerase II-Alpha, TOP2A, Topo II Alpha, Topoisomerase (DNA) II Alpha (170kD), Topoisomerase (DNA) II Alpha 170kDa, Topoisomerase, DNA, II, Alpha

Terms in Topoisomerase-II Alpha category



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