Cancer Terms

Topoisomerase-II Beta

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase -> Topoisomerase-II -> Topoisomerase-II Beta

Topoisomerase-II Beta Definition

Both topo II alpha and beta isoforms exhibit ATP-dependent strand passage activity, but they differ in several key aspects. The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement. The beta isoform has a molecular weight of 180 KD, and is immunologically distinct as well as exhibits different SV8 proteolytic cleavage pattern from alpha isoform.

Topoisomerase-II Beta Synonyms

Topoisomerase II Beta, DNA Topoisomerase II, 180 kD, DNA Topoisomerase II, Beta Isozyme, TOP2B, Topo II Beta, Topoisomerase (DNA) II Beta (180kD), Topoisomerase (DNA) II Beta 180kDa, Topoisomerase, DNA, II, Beta

Terms in Topoisomerase-II Beta category



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