Cancer Terms

Topoisomerase-III Alpha

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase -> Topoisomerase-III -> Topoisomerase-III Alpha

Topoisomerase-III Alpha Definition

Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Topoisomerase-III Alpha Synonyms

Topoisomerase III Alpha, DNA Topoisomerase III Alpha, TOP3A, TOPO III Alpha, Topo III-Alpha, Topoisomerase (DNA) III Alpha, Topoisomerase, DNA, III, Topoisomerase, DNA, III, Alpha

Terms in Topoisomerase-III Alpha category



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