Cancer Terms

Topoisomerase-III Beta

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Isomerase -> Topoisomerase -> Topoisomerase-III -> Topoisomerase-III Beta

Topoisomerase-III Beta Definition

Expressed as 3 alternative isoforms in testis, heart, skeletal muscle, thymus, kidney, and pancreas by human TOP3B Gene (Topoisomerase I/III Family), Topoisomerase III Beta is a DNA topoisomerase that interacts with DNA helicase SGS1; plays a role in DNA recombination, cellular aging, and maintenance of genome stability; and controls/alters DNA topology by relieving torsional stress in negatively supercoiled DNA during transcription. TOP3B catalyzes transient ATP-independent breaking and rejoining of DNA single-strands. Alternative C-terminal splicing results in three transcript variants that have distinct tissue specificity. (NCI)

Topoisomerase-III Beta Synonyms

Topoisomerase III Beta, DNA Topoisomerase III Beta, TOP3B, Topoisomerase IIIB

Terms in Topoisomerase-III Beta category



Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.