Transcription Factor-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Transcription Factor-3

Transcription Factor-3 Definition

Encoded by human TCF3 Gene, E12 and E47 alternative isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3 are homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI)

Transcription Factor-3 Synonyms

Transcription Factor 3, E2A, E2A Immunoglobulin Enhancer Binding Factor E12, E2A Immunoglobulin Enhancer Binding Factor E47, ITF1, Immunoglobulin Transcription Factor 1, Kappa-E2-Binding Factor, TCF3, Transcription Factor E2-Alpha

Transcription Factor-3

Transcription Factor-3 Definition

Transcription Factor-3 Synonyms

Terms in Transcription Factor-3 category