Transcription Factor-7-Like-2 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Transcription Factor-7-Like-2 Protein

Transcription Factor-7-Like-2 Protein Definition

Decreasingly expressed from crypt to villus by human TCF7L2 Gene (TCF/LEF Family), nuclear DNA-binding HMG box Transcription Factor 7-Like 2, participates in the WNT pathway and maintains epithelial stem cells of the small intestine. Absent CTNNB1, TCF7L2 acts as a repressor. Bound to the CTNNB1 armadillo repeat in a stable complex, TCF7L2 activates transcription from promoters containing the TCF motif (CCTTTGATC). TCF7L2 binds to the MYC promoter in a sequence-specific manner and modulates MYC expression. The TCF7L2 activation domain binds transcriptional coactivator EP300. TLE1, TLE2, TLE3, and TLE4 repress TCF7L2/CTNNB1 mediated transactivation. Constitutive TCF7L2 activation may promote maintenance of the stem cell phenotype and initiate colorectal cancer. TCF7L2/CTNNB1 may control proliferation versus differentiation in intestinal epithelial cells. (NCI)

Transcription Factor-7-Like-2 Protein Synonyms

Transcription Factor 7-Like 2, HMG Box Transcription Factor 4, T-Cell-Specific Transcription Factor 4, TCF4, TCF7L2, hTCF4

Terms in Transcription Factor-7-Like-2 Protein category

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