Transcription Factor-DP2
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Regulatory Protein ->
Transcription Regulatory Protein ->
Transcription Factor -> Transcription Factor-DP2
Transcription Factor-DP2 Definition
Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver, human TFDP2 Gene (E2F/DP Family) encodes alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, which in a heterodimeric complex with E2F family members regulates genes required for G1/S cell-cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. TFDP2 binds DNA cooperatively with E2F through the E2 recognition site, TTTCC/GCGC. Interact of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex. (NCI)
Transcription Factor-DP2 Synonyms
Transcription Factor Dp-2, DRTF1, E2F Dimerization Partner 2, TFDP2
Terms in Transcription Factor-DP2 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.