Transcription Initiation Factor-IIA Alpha Chain
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Transcription Initiation Factor-IIA Alpha Chain Definition
Encoded by human GTF2A1 Gene, Transcription Initiation Factor IIA Alpha Chain is a 35-kD subunit of general transcription initiation factor TFIIA that is post-translationally processed (N-terminal) with the 19-kD beta subunit (C-terminal) from the 55-kDa TFIIA Alpha p55 precursor. These subunits and the 12-kDa gamma subunit (GTF2A2 Gene) form a six strand beta-barrel that interacts with TBP and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. Accurate transcription initiation on class II genes involves ordered assembly of RNA polymerase II and general initiation factors. (NCI)
Transcription Initiation Factor-IIA Alpha Chain Synonyms
Transcription Initiation Factor IIA Alpha Chain, GTF2A1, TFIIA p35 Subunit
Terms in Transcription Initiation Factor-IIA Alpha Chain category
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