Cancer Terms

Transcription Initiation Factor-IIF Alpha Subunit

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> Transcription Initiation Factor-IIF Alpha Subunit

Transcription Initiation Factor-IIF Alpha Subunit Definition

Encoded by human GTF2F1 Gene, 74-kD Transcription Initiation Factor IIF Alpha Subunit is the large subunit of general transcription TFIIF, participating in initiation by RNA polymerase II. TFIIF binds to RNA polymerase II decreasing its affinity for nonspecific DNA and acts at an intermediate stage in initiation complex formation after TFIID associates with DNA, as RNA polymerase II binds to DNA, and before recruitment of TFIIE. GTF2F1 interacts with GTF2F2 to direct transcription initiation and is necessary for transcriptional activation by SRF. (NCI)

Transcription Initiation Factor-IIF Alpha Subunit Synonyms

Transcription Initiation Factor IIF Alpha Subunit, GTF2F1, General Transcription Factor IIF1 74kDa, TFIIF-Alpha, Transcription Initiation Factor RAP74

Terms in Transcription Initiation Factor-IIF Alpha Subunit category



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