Transcriptional Coactivator with PDZ-Binding Motif

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Coactivator -> Transcriptional Coactivator with PDZ-Binding Motif

Transcriptional Coactivator with PDZ-Binding Motif Definition

With highest expression in kidney, heart, placenta, and lung by human TAZ Gene, 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif contains a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI)

Transcriptional Coactivator with PDZ-Binding Motif Synonyms

WW Domain Containing Transcription Regulator 1, DKFZP586I1419, TAZ, Transcriptional Coactivator with PDZ-Binding Motif, WWTR1

Transcriptional Coactivator with PDZ-Binding Motif

Transcriptional Coactivator with PDZ-Binding Motif Definition

Transcriptional Coactivator with PDZ-Binding Motif Synonyms

Terms in Transcriptional Coactivator with PDZ-Binding Motif category