Transcriptional Coactivator-p52
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Regulatory Protein ->
Transcription Regulatory Protein ->
Transcription Coactivator -> Transcriptional Coactivator-p52
Transcriptional Coactivator-p52 Definition
Encoded by human PSIP1 Gene, Transcriptional Coactivator p52 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p75, but shows distinct coactivator properties. p52 interacts strongly with the VP16 activation domain and with components of the general transcriptional machinery. A potent broad-specificity coactivator, p52 interacts with transcriptional activators and general transcription factors, as well as with ASF/SF2 to modulate pre-mRNA splicing. Most p52 appears to be colocalized with ASF/SF2 in the nucleoplasm. p52 may coordinate pre-mRNA splicing and transcriptional activation of class II genes. (NCI)
Transcriptional Coactivator-p52 Synonyms
Transcriptional Coactivator p52, PAIP, PC4 and SFRS1 Interacting Protein 1, PC4 and SFRS1 Interacting Protein 2, PSIP1, PSIP2, p52
Terms in Transcriptional Coactivator-p52 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.