Cancer Terms

Transferrin Receptor-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Transferrin Receptor -> Transferrin Receptor-1

Transferrin Receptor-1 Definition

Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a glycosylated, phosphorylated, and palmitoylated type II membrane disulfide-linked homodimeric glycoprotein involved in cellular uptake of iron via receptor-mediated endocytosis. After intracellular iron release, apotransferrin-receptor is recycled to the cell surface with release of apotransferrin. Transferrin receptor appears necessary for nervous system and erythrocyte development, binds HLA class II histocompatibility antigen DR1, and binds parvoviruses that enter and infect cells. Ligand HFE competes with transferrin for binding to an overlapping C-terminal site. Proteolytic cleavage at Arg100 produces the glycosylated secreted sTfR isoform; used in a diagnostic test for anemia. (NCI)

Transferrin Receptor-1 Synonyms

Transferrin Receptor 1, CD71, CD71 Antigen, T9, TFR, TFR1, TFRC, TR, TRFR, Transferrin Receptor, Transferrin Receptor Protein 1, p90

Terms in Transferrin Receptor-1 category



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