Transformation

Cancer Terms -> Biological Process -> Pathologic Process -> Pathogenesis -> Tumor Initiation -> Transformation

Transformation Definition

The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events.

Transformation Synonyms

Transformation, Cell Transformation, Cellular Transformation, Transformed, Transforming, transformation

Terms in Transformation category

Malignant Conversion