Cancer Terms

Transformation-Transcription Domain-Associated Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Coactivator -> Transformation-Transcription Domain-Associated Protein

Transformation-Transcription Domain-Associated Protein Definition

Encoded by human TRRAP Gene (TRA1 Kinase Family), 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats, are a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI)

Transformation-Transcription Domain-Associated Protein Synonyms

Transformation/Transcription Domain-Associated Protein, 350/400 kDa PCAF-Associated Factor, PAF350/400, STAF40, TRA1 Homologue, TRRAP

Terms in Transformation-Transcription Domain-Associated Protein category



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