Transforming Growth Factor Beta Receptor-I

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Serine-Threonine Kinase -> Transforming Growth Factor Beta Receptor-I

Transforming Growth Factor Beta Receptor-I Definition

Expressed in all tissues (most in placenta) by human TGFBR1 Gene (TGFBR Ser/Thr Family), 503-aa 53-kDa (56-kDa precursor) Transforming Growth Factor Beta Receptor I is a type I transmembrane protein receptor for multifunctional cytokine TGFB1 containing a signal peptide, an extracellular Cys-rich region with an N-glycosylation site, a transmembrane region, and a cytoplasmic protein Ser/Thr kinase domain that mediates induction of cell-matrix adhesion genes and regulates cell cycle progression. TGF-beta binds either TGFBR1 or transmembrane Ser/Thr TGF-Beta II receptor, which form an active heterodimeric complex. TGFB stimulation leads to phosphorylation and activation of SMAD2 and SMAD3, which, complexed with SMAD4, accumulate in the nucleus and regulate transcription of target genes. Continuous SMAD nucleocytoplasmic shuttling during TGFB signaling monitors receptor activity. (NCI)

Transforming Growth Factor Beta Receptor-I Synonyms

Transforming Growth Factor Beta Receptor I, ALK5, Activin A Receptor Type II-Like Kinase 53kDa, Activin Receptor-Like Kinase 5, SKR4, Serine/Threonine-Protein Kinase Receptor R4, TGF-Beta Receptor Type I, TGF-Beta Type I Receptor, TGFBR1, Transforming Growth Factor Beta Receptor Type I

Terms in Transforming Growth Factor Beta Receptor-I category

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