Transforming Protein-ERG
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Transforming Protein-ERG Definition
A member of the ETS family of transcription factors closely related to FLI1, Transforming Protein ERG shows homology to two domains of the ETS oncogene. ERG1 and ERG2 are products of alternative splicing and polyadenylation, as well as translation initiation. ERG2 is a nuclear phosphoprotein that binds to purine-rich sequences. Like other ETS proteins, ERG2 is a sequence-specific DNA-binding protein and expressed at higher levels in early myeloid cells than in mature lymphoid cells. ERG2 acts as a regulator of genes required for maintenance and/or differentiation of early hematopoietic cells. (from OMIM 165080 and NCI)
Transforming Protein-ERG Synonyms
Transcriptional Regulator ERG, ERG, ERG1, ERG2, Transforming Protein ERG
Terms in Transforming Protein-ERG category
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