Cancer Terms

Treosulfan

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Alkylsulfonate Compound -> Treosulfan

Treosulfan Definition

The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities.

Treosulfan Synonyms

Treosulfan, (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate, 1,2,3, 4-Butanetetrol, 1,4-dimethanesulfonate, [R-(R*,S*)]-, Dihydroxybusulfan, L-Threitol 1,4-dimethanesulfonate, Ovastat, Treosulphan, Tresulfon, treosulfan

Terms in Treosulfan category



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