Trimethadione
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Agent Affecting Nervous System ->
Anticonvulsant Agent -> Trimethadione
Trimethadione Definition
A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing neuronal membranes, raising the threshold for repetitive activities in the thalamus and inhibiting corticothalamic transmission. This decreases the abnormal thalamocortical rhythmicity, which is thought to underlie the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures.
Trimethadione Synonyms
Trimethadione, 2,4-Oxazolidinedione, 3,5,5-trimethyl-, TRIMETHADIONE, Tridione
Terms in Trimethadione category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.