Cancer Terms

Triple Functional Domain Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Guanine Nucleotide Exchange Factor -> Triple Functional Domain Protein

Triple Functional Domain Protein Definition

Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney, and lung by human TRIO Gene (Ser/Thr Kinase Family), 3038-aa 342-kDa serine phosphorylated Triple Functional Domain Protein contains a Ser/Thr kinase domain, 2 DH domains, a CRAL-TRIO domain, an Ig-like C2-type domain, 2 PH domains, an SH3 domain, and 4 spectrin repeats. The N-terminal DBL(DH)/GEF domain catalyzes RAC1 GDP/GTP exchange, leading to JUN kinase activation and membrane ruffling. The second DBL(DH)/GEF domain catalyzes RHOA GDP/GTP exchange, inducing stress fiber formation. Interacting with the cytoplasmic region of LAR tyrosine phosphatase, TRIO may coordinate cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. (NCI)

Triple Functional Domain Protein Synonyms

Triple Functional Domain Protein, PTPRF Interacting Protein, TRIO

Terms in Triple Functional Domain Protein category



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