Tubulin Inhibitor CYT997
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Tubulin Inhibitor CYT997 Definition
An orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Vascular disrupting agent (VDA) CYT997 inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.
Tubulin Inhibitor CYT997 Synonyms
Tubulin Inhibitor CYT997, CYT997
Terms in Tubulin Inhibitor CYT997 category
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