Cancer Terms

Tumor Necrosis Factor Alpha Receptor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> TNF Receptor Family Protein -> Tumor Necrosis Factor Alpha Receptor

Tumor Necrosis Factor Alpha Receptor Definition

TNFR1 is a 55 kD high-affinity cell surface receptor for tumor necrosis factor. Activated receptor interacts with death domains of TRADD to activate apoptosis and NFKB cascades. TRADD-interacting FADD proteolytically activates caspase-8. TNFR1 may activate PIP5K2B and may induce MAP kinase activation via MADD. (from OMIM 191190 and NCI)

Tumor Necrosis Factor Alpha Receptor Synonyms

Tumor Necrosis Factor Receptor Superfamily, Member 1A, TNFRSF1A, Tumor Necrosis Factor Binding Protein 1, Tumor Necrosis Factor Receptor Type 1, Tumor Necrosis Factor-Alpha Receptor

Terms in Tumor Necrosis Factor Alpha Receptor category



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