Cancer Terms

Tyrosine Kinase Inhibitor MGCD265

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Tyrosine Kinase Inhibitor -> Tyrosine Kinase Inhibitor MGCD265

Tyrosine Kinase Inhibitor MGCD265 Definition

An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs.

Tyrosine Kinase Inhibitor MGCD265 Synonyms

Multitargeted Tyrosine Kinase Inhibitor MGCD265, MGCD265, TKI MGCD265

Terms in Tyrosine Kinase Inhibitor MGCD265 category



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