Tyrosine Phosphatase SHP Substrate-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Tyrosine Phosphatase SHP Substrate-1

Tyrosine Phosphatase SHP Substrate-1 Definition

Encoded as 3 isoforms by human PTPNS1 Gene (SIRP/Ig Families), ubiquitous (high in brain) N-glycosylated Tyrosine Phosphatase SHP Substrate 1 is a type I membrane protein cell surface CD47 receptor that contains an Ig-V-type and 2 Ig-C1-type domains. A negative receptor tyrosine kinase regulator to cell adhesion, growth factors, or insulin and phosphorylated by receptor signal transduction, PTPNS1 recruits SH2 domain PTPs as signaling PTP substrates. PTPNS1 induces membrane translocation of PTPN6, -11, and other cytosolic partners; negatively regulates phagocytosis, mast cell activation, and dendritic cell activation/maturation; and regulates neural adhesion, neurite outgrowth, glial attachment, synaptogenesis, and synaptic function. Dephosphorylated by PTPN11 (PTPN6 in macrophages), PTPNS1 appears to bind GRB2, PTK2B, and FGR; forms a stable complex with JAK2; and binds SCAP1/SCAP2, recruiting FYB. (NCI)

Tyrosine Phosphatase SHP Substrate-1 Synonyms

Tyrosine Phosphatase SHP Substrate-1, BIT, Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs, Inhibitory Receptor SHPS-1, MFR, MYD-1 Antigen, MYD1, Macrophage Fusion Receptor, PTPNS1, Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1, SHP Substrate-1, SHPS1, SIRP, SIRP Alpha, SIRP Alpha 1, SIRP Alpha 2, SIRP Alpha 3, Signal Regulatory Protein Alpha Type 1, Signal Regulatory Protein Alpha Type 2, Signal-Regulatory Protein Alpha-1, p84

Tyrosine Phosphatase SHP Substrate-1

Tyrosine Phosphatase SHP Substrate-1 Definition

Tyrosine Phosphatase SHP Substrate-1 Synonyms

Terms in Tyrosine Phosphatase SHP Substrate-1 category