Cancer Terms

UGT1A1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Glycosyltransferase -> UGT1A1 Protein

UGT1A1 Protein Definition

Expressed in liver by human UGT1A1 Gene (UDPGT Family), 533-aa 60-kDa (precursor) microsomal UDP-Glucuronosyltransferase 1A1 variants, with unique N-termini (and substrate specificity) preceding a common conserved 245-aa C-terminus, are involved in detoxification. Catalyzing glycosyl addition from a nucleotide sugar to a hydrophobic molecule, UDPGTs represent a major glucuronidation pathway in conjugation and elimination of toxic lipophilic xeno- and endobiotics to water-soluble compounds. UGT1A1 glucuronidates its preferred substrate bilirubin and acts on simple phenols, flavones, and C18 steroids. UGT1A1 may be a major gene controlling serum bilirubin levels. (NCI)

UGT1A1 Protein Synonyms

UDP-Glucuronosyltransferase 1A1, Bilirubin Specific UDPGT Isozyme 1, HUG-BR1, UDP-Glucuronosyltransferase 1-1, UDPGT, UGT1A, UGT1A1

Terms in UGT1A1 Protein category



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