Cancer Terms

Uniroyal Compound

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Antiviral Agent -> Anti-HIV Agent -> Uniroyal Compound

Uniroyal Compound Definition

A thiocarboxanilide derivative, belongs to the second generation of non-nucleoside reverse transcriptase inhibitors (NNRTI), with anti-viral activity. Uniroyal compound 38 (UC-38), is a non-competitive inhibitor of HIV type 1 (HIV-1) reverse transcriptase (RT), which catalyzes the conversion of genomic RNA into double-stranded pro-viral DNA after cell entry. UC-38 binds to a hydrophobic pocket close to but distinct from the polymerase active site in the p66 subunit and inhibits enzyme activity by mediating allosteric changes in the RT. Inhibition of HIV-1 RT results in termination of viral proliferation.

Uniroyal Compound Synonyms

Uniroyal Compound-38, 1-methylethyl-2-chloro-5-[[5,6-dihydro-2-methyl- 1, 4-oxathiin-3-yl-carbonyl]-amino]benzoate, 2-Chloro-5-(((1-methylethoxy)thioxomethyl)amino)benzoic acid, UC-38, UC38, Uniroyal Jr.

Terms in Uniroyal Compound category



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