Cancer Terms

Urokinase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Serine Protease -> Plasminogen Activator -> Urokinase

Urokinase Definition

Encoded by human PLAU Gene (Peptidase S1 Family), 431-aa 48.5-kD single-chain Urokinase precursor contains a kringle and an EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Urokinase Synonyms

Urokinase, PLAU, Plasminogen Activator, Urinary, Plasminogen Activator, Urokinase, U-Plasminogen Activator, Urinary Plasminogen Activator, Urokinase Plasminogen Activator, Urokinase-Type Plasminogen Activator, u-PA, uPA

Terms in Urokinase category



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