V-D-J Recombination
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Immunoglobulin Gene Rearrangement -> V-D-J Recombination
V-D-J Recombination Definition
By a cascade of temporally ordered translocation steps during B-cell development, V(D)J Recombination randomly joins discrete DNA segments that encode antibody variable-V, diversity-D, and joining-J, segments of the coding sequence for a single heavy or light chain gene. DNA recombinases recognize a palindromic heptamer and an AT-rich nonamer separated by a 12 or 23bp spacer recombination signal sequence (RSS) neighboring the coding regions; create double-stranded DNA breaks at the exon/RSS boundaries; excise intervening DNA; and ligate the DNA ends to create a contiguous reading frame.
V-D-J Recombination Synonyms
V(D)J Recombination, Immunoglobulin V(D)J Rearrangement, V(D)J Rearrangement
Terms in V-D-J Recombination category
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