VAV Family Gene

Cancer Terms -> Gene -> Signaling Pathway Gene -> VAV Family Gene

VAV Family Gene Definition

VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for Rho/Rac family GTPases, which activate pathways leading to actin cytoskeletal rearrangements, transcriptional alterations, cell differentiation, and/or cell proliferation. VAV proteins contain CH, DH, PH, SH2, SH3, and zinc-dependent phorbol-ester and DAG binding domains. VAV1 is expressed exclusively in hematopoietic cells, while VAV2 and VAV3 are more broadly expressed. (NCI)

VAV Family Gene Synonyms

VAV Family Gene

Terms in VAV Family Gene category

VAV1 Gene
VAV2 Gene
VAV3 Gene