Cancer Terms

Varenicline

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Nervous System -> Cholinergic Agonist -> Nicotinic Agonist -> Varenicline

Varenicline Definition

A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself.

Varenicline Synonyms

Varenicline, 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate, CP-526555, Champix, Chantix, VARENICLINE

Terms in Varenicline category



Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.