Vascular Endothelial Growth Factor Receptor
Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Growth Factor Receptor -> Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor Receptor Definition
There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor.Vascular Endothelial Growth Factor Receptor Synonyms
Vascular Endothelial Growth Factor Receptor, Receptor, Vascular Endothelial Growth Factor, VEGFRTerms in Vascular Endothelial Growth Factor Receptor category
FMS-Related Tyrosine Kinase-4Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2