Vasopressin Receptor
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Vasopressin Receptor Definition
Neurohypophyseal vasopressin is a cyclic nonapeptide involved in diverse actions, including the control of body fluid osmolality, blood volume, blood pressure, vascular tone, hepatic glycogenolysis, vascular smooth muscle and mesangial cell contraction, nephric antidiuresis, and platelet aggregation. Vasopressin binds to three GPCR subtypes: V1A, V1B, and V2. The V1A receptor is located in liver, vascular smooth muscle, brain, mesangial cells, and platelets. It mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor, and glycogenolysis. V1A and V1B activate PLC via Gq/11, which increases intracellular calcium. Arginine VP modulates ACTH, beta-endorphin, and prolactin release, mediated by V1B. V2 is expressed exclusively in the kidney and mediates the antidiuretic effect of arginine VP by activating adenylyl cyclase via interaction with Gs. (from OMIM 600821, 600264, and NCI)
Vasopressin Receptor Synonyms
Vasopressin Receptor
Terms in Vasopressin Receptor category
Arginine Vasopressin Receptor-1AArginine Vasopressin Receptor-1BArginine Vasopressin Receptor-2
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