Vatalanib Succinate
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Vatalanib Succinate Definition
The succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.
Vatalanib Succinate Synonyms
Vatalanib Succinate, 1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate, Butanedioic Acid, Compd. with N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1), CGP 79787D, PTK 787, PTK-787, PTK787, PTK787/ZK 222584, VATALANIB SUCCINATE, ZK 222584
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